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[[Image:2dyl.jpg|left|200px]]


{{Structure
==Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)==
|PDB= 2dyl |SIZE=350|CAPTION= <scene name='initialview01'>2dyl</scene>, resolution 2.45&Aring;
<StructureSection load='2dyl' size='340' side='right'caption='[[2dyl]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2dyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DYL FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyl OCA], [https://pdbe.org/2dyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dyl RCSB], [https://www.ebi.ac.uk/pdbsum/2dyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dyl ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyl OCA], [http://www.ebi.ac.uk/pdbsum/2dyl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dyl RCSB]</span>
[https://www.uniprot.org/uniprot/MP2K7_HUMAN MP2K7_HUMAN] Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.<ref>PMID:9372971</ref> <ref>PMID:9312068</ref> <ref>PMID:9535930</ref> [:]
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/2dyl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dyl ConSurf].
<div style="clear:both"></div>


'''Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)'''
==See Also==
 
*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2DYL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYL OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Kaminishi T]]
[[Category: Kaminishi, T.]]
[[Category: Kukimoto-Niino M]]
[[Category: Kukimoto-Niino, M.]]
[[Category: Matsuzaki O]]
[[Category: Matsuzaki, O.]]
[[Category: Shirouzu M]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Takagi T]]
[[Category: Shirouzu, M.]]
[[Category: Terada T]]
[[Category: Takagi, T.]]
[[Category: Uchikubo-Kamo T]]
[[Category: Terada, T.]]
[[Category: Yokoyama S]]
[[Category: Uchikubo-Kamo, T.]]
[[Category: Yokoyama, S.]]
[[Category: activated mutant]]
[[Category: atp-binding]]
[[Category: kinase]]
[[Category: mkk7]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:41:17 2008''
Retrieved from "https://proteopedia.org/2dyl"