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[[Image:2dyn.gif|left|200px]]


{{Structure
==DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)==
|PDB= 2dyn |SIZE=350|CAPTION= <scene name='initialview01'>2dyn</scene>, resolution 2.30&Aring;
<StructureSection load='2dyn' size='340' side='right'caption='[[2dyn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2dyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DYN FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyn OCA], [https://pdbe.org/2dyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dyn RCSB], [https://www.ebi.ac.uk/pdbsum/2dyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dyn ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyn OCA], [http://www.ebi.ac.uk/pdbsum/2dyn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dyn RCSB]</span>
[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/2dyn_consurf.spt"</scriptWhenChecked>
==Overview==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
The pleckstrin homology (PH) domain is a conserved module present in many signal transducing and cytoskeletal proteins. Here we report the 2.8 A crystal structure of the PH domain from dynamin. This domain consists of seven beta-strands forming two roughly orthogonal antiparallel beta-sheets terminating with an amphipathic alpha-helix. The structure also reveals a non-covalent dimeric association of the PH domain and a hydrophobic pocket surrounded by a charged rim. The dynamin PH domain structure is discussed in relation to its potential role in mediating interactions between proteins.
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dyn ConSurf].
2DYN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of the pleckstrin homology domain from dynamin., Timm D, Salim K, Gout I, Guruprasad L, Waterfield M, Blundell T, Nat Struct Biol. 1994 Nov;1(11):782-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7634088 7634088]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Timm, D E.]]
[[Category: Timm DE]]
[[Category: motor protein]]
[[Category: phospholipid binding]]
[[Category: protein binding]]
[[Category: signal transduction]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:41:20 2008''

Latest revision as of 09:19, 14 February 2024

DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)

2dyn, resolution 2.30Å

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