1sqn: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Progesterone Receptor Ligand Binding Domain with bound Norethindrone== | ==Progesterone Receptor Ligand Binding Domain with bound Norethindrone== | ||
<StructureSection load='1sqn' size='340' side='right' caption='[[1sqn]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='1sqn' size='340' side='right'caption='[[1sqn]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1sqn]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1sqn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQN FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.451Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDR:(14BETA,17ALPHA)-17-ETHYNYL-17-HYDROXYESTR-4-EN-3-ONE'>NDR</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqn OCA], [https://pdbe.org/1sqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sqn RCSB], [https://www.ebi.ac.uk/pdbsum/1sqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqn ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 16: | Line 15: | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sqn_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sqn_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| Line 30: | Line 29: | ||
</div> | </div> | ||
<div class="pdbe-citations 1sqn" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1sqn" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Progesterone receptor|Progesterone receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Austin | [[Category: Large Structures]] | ||
[[Category: Deng | [[Category: Austin RJH]] | ||
[[Category: Lambert | [[Category: Deng J-S]] | ||
[[Category: Madauss | [[Category: Lambert MH]] | ||
[[Category: McLay | [[Category: Madauss KP]] | ||
[[Category: Pritchard | [[Category: McLay I]] | ||
[[Category: Short | [[Category: Pritchard J]] | ||
[[Category: Stewart | [[Category: Short SA]] | ||
[[Category: Uings | [[Category: Stewart EL]] | ||
[[Category: Williams | [[Category: Uings IJ]] | ||
[[Category: Williams SP]] | |||
