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==Solution structure of the A147T variant of the mitochondrial translocator protein (tspo) in complex with pk11195==
==Solution structure of the A147T variant of the mitochondrial translocator protein (tspo) in complex with pk11195==
<StructureSection load='2n02' size='340' side='right' caption='[[2n02]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2n02' size='340' side='right'caption='[[2n02]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2n02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N02 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2n02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N02 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PKA:N-[(2R)-BUTAN-2-YL]-1-(2-CHLOROPHENYL)-N-METHYLISOQUINOLINE-3-CARBOXAMIDE'>PKA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mgy|2mgy]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PKA:N-[(2R)-BUTAN-2-YL]-1-(2-CHLOROPHENYL)-N-METHYLISOQUINOLINE-3-CARBOXAMIDE'>PKA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bzrp, Tspo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n02 OCA], [https://pdbe.org/2n02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n02 RCSB], [https://www.ebi.ac.uk/pdbsum/2n02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n02 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n02 OCA], [http://pdbe.org/2n02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n02 RCSB], [http://www.ebi.ac.uk/pdbsum/2n02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n02 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TSPO_MOUSE TSPO_MOUSE] Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060).<ref>PMID:24174323</ref> <ref>PMID:24814875</ref> <ref>PMID:24936060</ref> <ref>PMID:8114671</ref> <ref>PMID:9832438</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Becker, S]]
[[Category: Mus musculus]]
[[Category: Giller, K]]
[[Category: Becker S]]
[[Category: Jaremko, L]]
[[Category: Giller K]]
[[Category: Jaremko, M]]
[[Category: Jaremko L]]
[[Category: Zweckstetter, M]]
[[Category: Jaremko M]]
[[Category: A147t]]
[[Category: Zweckstetter M]]
[[Category: Membrane protein]]
[[Category: Mitochondria]]
[[Category: Peripheral benzodiazepine receptor]]
[[Category: Pk11195]]
[[Category: Protein-ligand complex]]
Retrieved from "https://proteopedia.org/2n02"