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==Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead==
==Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead==
<StructureSection load='3ovz' size='340' side='right' caption='[[3ovz]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
<StructureSection load='3ovz' size='340' side='right'caption='[[3ovz]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ovz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OVZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ovz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OVZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O96:N-[(1S)-3-AMINO-1-ETHYL-2,3-DIOXOPROPYL]-2-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-3-(TRIFLUOROMETHYL)BENZAMIDE'>O96</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ovx|3ovx]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O96:N-[(1S)-3-AMINO-1-ETHYL-2,3-DIOXOPROPYL]-2-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-3-(TRIFLUOROMETHYL)BENZAMIDE'>O96</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ovz OCA], [https://pdbe.org/3ovz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ovz RCSB], [https://www.ebi.ac.uk/pdbsum/3ovz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ovz ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ovz OCA], [http://pdbe.org/3ovz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ovz RCSB], [http://www.ebi.ac.uk/pdbsum/3ovz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ovz ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.  
[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3ovz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3ovz" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cathepsin K]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Fradera, X]]
[[Category: Fradera X]]
[[Category: Uitdehaag, J C.M]]
[[Category: Uitdehaag JCM]]
[[Category: Zeeland, M van]]
[[Category: Van Zeeland M]]
[[Category: Cathepsin k]]
[[Category: Covalent inhibitor]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Ketoamide warhead]]
[[Category: Ligand forms covalent bond to cys25]]
[[Category: Lysosome]]
Retrieved from "https://proteopedia.org/3ovz"