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[[Image:2e3k.jpg|left|200px]]


{{Structure
==Crystal structure of the human Brd2 second bromodomain in complexed with the acetylated histone H4 peptide==
|PDB= 2e3k |SIZE=350|CAPTION= <scene name='initialview01'>2e3k</scene>, resolution 2.30&Aring;
<StructureSection load='2e3k' size='340' side='right'caption='[[2e3k]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>
<table><tr><td colspan='2'>[[2e3k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3K FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= BRD2, KIAA9001, RING3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3k OCA], [https://pdbe.org/2e3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3k RCSB], [https://www.ebi.ac.uk/pdbsum/2e3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3k ProSAT]</span></td></tr>
|RELATEDENTRY=[[2dvv|2DVV]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3k OCA], [http://www.ebi.ac.uk/pdbsum/2e3k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2e3k RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/2e3k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e3k ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the human Brd2 second bromodomain in complexed with the acetylated histone H4 peptide'''
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
2E3K is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3K OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Padmanabhan, B.]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Padmanabhan B]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: binds to acetylated histone tail]]
[[Category: bromodomain]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: transcription]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:43:15 2008''

Latest revision as of 08:34, 25 October 2023

Crystal structure of the human Brd2 second bromodomain in complexed with the acetylated histone H4 peptide

2e3k, resolution 2.30Å

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