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==Crystal structure of streptogramin A acetyltransferase with dalfopristin==
==Crystal structure of streptogramin A acetyltransferase with dalfopristin==
<StructureSection load='1mrl' size='340' side='right' caption='[[1mrl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1mrl' size='340' side='right'caption='[[1mrl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1mrl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MRL FirstGlance]. <br>
<table><tr><td colspan='2'>[[1mrl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MRL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOL:5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE'>DOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mr7|1mr7]], [[1mr9|1mr9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOL:5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE'>DOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mrl OCA], [http://pdbe.org/1mrl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mrl RCSB], [http://www.ebi.ac.uk/pdbsum/1mrl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mrl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mrl OCA], [https://pdbe.org/1mrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mrl RCSB], [https://www.ebi.ac.uk/pdbsum/1mrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mrl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VATD_ENTFC VATD_ENTFC]] Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.  
[https://www.uniprot.org/uniprot/VATD_ENTFC VATD_ENTFC] Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 19434]]
[[Category: Enterococcus faecium]]
[[Category: Courvalin, P]]
[[Category: Large Structures]]
[[Category: Kehoe, L E]]
[[Category: Courvalin P]]
[[Category: Murray, I A]]
[[Category: Kehoe LE]]
[[Category: Rafferty, J B]]
[[Category: Murray IA]]
[[Category: Snidwongse, J]]
[[Category: Rafferty JB]]
[[Category: Left-handed parallel beta-helix domain]]
[[Category: Snidwongse J]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1mrl"