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[[Image:2e5w.gif|left|200px]]


{{Structure
==Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3==
|PDB= 2e5w |SIZE=350|CAPTION= <scene name='initialview01'>2e5w</scene>, resolution 2.00&Aring;
<StructureSection load='2e5w' size='340' side='right'caption='[[2e5w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AG3:1-{4-[(3-AMINOPROPYL)AMINO]BUTYL}GUANIDINE'>AG3</scene>, <scene name='pdbligand=MTA:5&#39;-DEOXY-5&#39;-METHYLTHIOADENOSINE'>MTA</scene>
<table><tr><td colspan='2'>[[2e5w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5W FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AG3:1-{4-[(3-AMINOPROPYL)AMINO]BUTYL}GUANIDINE'>AG3</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5w OCA], [https://pdbe.org/2e5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5w RCSB], [https://www.ebi.ac.uk/pdbsum/2e5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5w ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5w TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5w OCA], [http://www.ebi.ac.uk/pdbsum/2e5w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2e5w RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/SPEE_PYRHO SPEE_PYRHO] Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine (By similarity).[HAMAP-Rule:MF_00198]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5w_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5w ConSurf].
<div style="clear:both"></div>


'''Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3'''
==See Also==
 
*[[Spermidine synthase 3D structures|Spermidine synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2E5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5W OCA].
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: Single protein]]
[[Category: Kunishima N]]
[[Category: Spermidine synthase]]
[[Category: Mizutani H]]
[[Category: Kunishima, N.]]
[[Category: Mizutani, H.]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: spermidine synthase]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:44:09 2008''

Latest revision as of 08:35, 25 October 2023

Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3

2e5w, resolution 2.00Å

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