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==PyrR, the regulator of the pyrimidine biosynthetic operon in Bacillus caldolyticus==
==PyrR, the regulator of the pyrimidine biosynthetic operon in Bacillus caldolyticus==
<StructureSection load='1non' size='340' side='right' caption='[[1non]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1non' size='340' side='right'caption='[[1non]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1non]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_caldolyticus"_heinen_and_heinen_1972 "bacillus caldolyticus" heinen and heinen 1972]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NON FirstGlance]. <br>
<table><tr><td colspan='2'>[[1non]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_caldolyticus Bacillus caldolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NON FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a3c|1a3c]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pyrr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1394 "Bacillus caldolyticus" Heinen and Heinen 1972])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1non FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1non OCA], [https://pdbe.org/1non PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1non RCSB], [https://www.ebi.ac.uk/pdbsum/1non PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1non ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil_phosphoribosyltransferase Uracil phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.9 2.4.2.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1non FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1non OCA], [http://pdbe.org/1non PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1non RCSB], [http://www.ebi.ac.uk/pdbsum/1non PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1non ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYRR_BACCL PYRR_BACCL]] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable).  Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.  
[https://www.uniprot.org/uniprot/PYRR_BACCL PYRR_BACCL] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable).  Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus caldolyticus heinen and heinen 1972]]
[[Category: Large Structures]]
[[Category: Uracil phosphoribosyltransferase]]
[[Category: Bonner HK]]
[[Category: Bonner, H K]]
[[Category: Chander P]]
[[Category: Chander, P]]
[[Category: Grabner GK]]
[[Category: Grabner, G K]]
[[Category: Halbig KM]]
[[Category: Halbig, K M]]
[[Category: Miller JK]]
[[Category: Miller, J K]]
[[Category: Smith JL]]
[[Category: Smith, J L]]
[[Category: Switzer RL]]
[[Category: Switzer, R L]]
[[Category: Attenuation protein]]
[[Category: Bifunctional enzyme]]
[[Category: Prtase]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Rna-binding protein]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transferase]]
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