6bzp: Difference between revisions

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'''Unreleased structure'''


The entry 6bzp is ON HOLD  until Paper Publication
==STGGYG from low-complexity domain of FUS, residues 77-82==
 
<StructureSection load='6bzp' size='340' side='right'caption='[[6bzp]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
Authors: Hughes, M.P., Rodriguez, J.A., Sawaya, M.R., Cascio, D., Gonen, T., Eisenberg, D.S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6bzp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BZP FirstGlance]. <br>
Description: STGGYG from low-complexity domain of FUS, residues 77-82
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>
[[Category: Gonen, T]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzp OCA], [https://pdbe.org/6bzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bzp RCSB], [https://www.ebi.ac.uk/pdbsum/6bzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzp ProSAT]</span></td></tr>
[[Category: Rodriguez, J.A]]
</table>
[[Category: Eisenberg, D.S]]
== Disease ==
[[Category: Cascio, D]]
[https://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN] Frontotemporal dementia with motor neuron disease;Hereditary essential tremor;Amyotrophic lateral sclerosis;Juvenile amyotrophic lateral sclerosis;Myxofibrosarcoma;Myxoid/round cell liposarcoma. A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3.  A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG.  The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
[[Category: Sawaya, M.R]]
== Function ==
[[Category: Hughes, M.P]]
[https://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN] Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cascio D]]
[[Category: Eisenberg DS]]
[[Category: Gonen T]]
[[Category: Hughes MP]]
[[Category: Rodriguez JA]]
[[Category: Sawaya MR]]
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