6c6k: Difference between revisions
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==Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex== | |||
<StructureSection load='6c6k' size='340' side='right'caption='[[6c6k]], [[Resolution|resolution]] 2.54Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Equine_encephalosis_virus Equine encephalosis virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C6K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6k OCA], [https://pdbe.org/6c6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c6k RCSB], [https://www.ebi.ac.uk/pdbsum/6c6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6k ProSAT]</span></td></tr> | ||
[[Category: Johnson | </table> | ||
[[Category: | == Function == | ||
[[Category: Xu | [https://www.uniprot.org/uniprot/IFIT1_HUMAN IFIT1_HUMAN] Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<ref>PMID:19008854</ref> <ref>PMID:19416887</ref> <ref>PMID:21976647</ref> <ref>PMID:23334420</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Equine encephalosis virus]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Amarasinghe GK]] | |||
[[Category: Johnson B]] | |||
[[Category: Leung DW]] | |||
[[Category: Xu W]] | |||
Latest revision as of 14:32, 6 March 2024
Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex
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