6ccg: Difference between revisions

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'''Unreleased structure'''


The entry 6ccg is ON HOLD
==Crystal structure MBD3 MBD domain in complex with methylated CpG DNA==
<StructureSection load='6ccg' size='340' side='right'caption='[[6ccg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ccg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CCG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ccg OCA], [https://pdbe.org/6ccg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ccg RCSB], [https://www.ebi.ac.uk/pdbsum/6ccg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ccg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MBD3_HUMAN MBD3_HUMAN] Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases.<ref>PMID:9774669</ref> <ref>PMID:10947852</ref> <ref>PMID:12124384</ref>


Authors: Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
==See Also==
 
*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
Description: Crystal structure MBD3 MBD domain in complex with methylated CpG DNA
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Arrowsmith, C.H]]
__TOC__
[[Category: Liu, K]]
</StructureSection>
[[Category: Min, J]]
[[Category: Homo sapiens]]
[[Category: Edwards, A.M]]
[[Category: Large Structures]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Synthetic construct]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Tempel, W]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: Liu K]]
[[Category: Min J]]
[[Category: Tempel W]]
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