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[[Image:2ejv.jpg|left|200px]]


{{Structure
==Crystal structure of threonine 3-dehydrogenase complexed with NAD+==
|PDB= 2ejv |SIZE=350|CAPTION= <scene name='initialview01'>2ejv</scene>, resolution 2.55&Aring;
<StructureSection load='2ejv' size='340' side='right'caption='[[2ejv]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+502'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+B+501'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Residue+B+502'>AC4</scene>, <scene name='pdbsite=AC5:Nad+Binding+Site+For+Residue+B+2350'>AC5</scene> and <scene name='pdbsite=AC6:Nad+Binding+Site+For+Residue+A+1350'>AC6</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[2ejv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EJV FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK05396 tdh], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00107 ADH_zinc_N], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam08240 ADH_N]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ejv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ejv OCA], [https://pdbe.org/2ejv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ejv RCSB], [https://www.ebi.ac.uk/pdbsum/2ejv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ejv ProSAT], [https://www.topsan.org/Proteins/RSGI/2ejv TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ejv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ejv OCA], [http://www.ebi.ac.uk/pdbsum/2ejv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ejv RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/TDH_THET8 TDH_THET8]
 
== Evolutionary Conservation ==
'''Crystal structure of threonine 3-dehydrogenase complexed with NAD+'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/2ejv_consurf.spt"</scriptWhenChecked>
2EJV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJV OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: L-threonine 3-dehydrogenase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Single protein]]
  </jmolCheckbox>
[[Category: Thermus thermophilus]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ejv ConSurf].
[[Category: Goto, M.]]
<div style="clear:both"></div>
[[Category: Hirotsu, K.]]
__TOC__
[[Category: Miyahara, I.]]
</StructureSection>
[[Category: Omi, R.]]
[[Category: Large Structures]]
[[Category: Yao, T.]]
[[Category: Thermus thermophilus HB8]]
[[Category: nad-dependent]]
[[Category: Goto M]]
[[Category: oxidoreductase]]
[[Category: Hirotsu K]]
 
[[Category: Miyahara I]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:50:16 2008''
[[Category: Omi R]]
[[Category: Yao T]]
Retrieved from "https://proteopedia.org/2ejv"