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==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
<StructureSection load='4a33' size='340' side='right' caption='[[4a33]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4a33' size='340' side='right'caption='[[4a33]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A33 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A33 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a32|4a32]], [[4a2z|4a2z]], [[4a30|4a30]], [[2wsa|2wsa]], [[4a31|4a31]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [https://pdbe.org/4a33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [https://www.ebi.ac.uk/pdbsum/4a33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a33 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [http://pdbe.org/4a33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [http://www.ebi.ac.uk/pdbsum/4a33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a33 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).  
[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
[[Category: Large Structures]]
[[Category: Leima]]
[[Category: Leishmania major]]
[[Category: Brand, S]]
[[Category: Brand S]]
[[Category: Brenk, R]]
[[Category: Brenk R]]
[[Category: Cleghorn, L A.T]]
[[Category: Cleghorn LAT]]
[[Category: Fairlamb, A H]]
[[Category: Fairlamb AH]]
[[Category: Ferguson, M A.J]]
[[Category: Ferguson MAJ]]
[[Category: Frearson, J A]]
[[Category: Frearson JA]]
[[Category: Gilbert, I H]]
[[Category: Gilbert IH]]
[[Category: Hallyburton, I]]
[[Category: Hallyburton I]]
[[Category: Harrison, J R]]
[[Category: Harrison JR]]
[[Category: McElroy, S P]]
[[Category: McElroy SP]]
[[Category: Norcross, N R]]
[[Category: Norcross NR]]
[[Category: Norval, S]]
[[Category: Norval S]]
[[Category: Read, K D]]
[[Category: Read KD]]
[[Category: Robinson, D A]]
[[Category: Robinson DA]]
[[Category: Smith, V C]]
[[Category: Smith VC]]
[[Category: Spinks, D]]
[[Category: Spinks D]]
[[Category: Stojanovski, L]]
[[Category: Stojanovski L]]
[[Category: Torrie, L S]]
[[Category: Torrie LS]]
[[Category: Wyatt, P G]]
[[Category: Wyatt PG]]
[[Category: Drug discovery]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4a33"