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==Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody==
==Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody==
<StructureSection load='5tud' size='340' side='right' caption='[[5tud]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5tud' size='340' side='right'caption='[[5tud]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5tud]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TUD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5tud]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TUD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nc3|4nc3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HTR2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tud OCA], [https://pdbe.org/5tud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tud RCSB], [https://www.ebi.ac.uk/pdbsum/5tud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tud ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tud OCA], [http://pdbe.org/5tud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tud RCSB], [http://www.ebi.ac.uk/pdbsum/5tud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tud ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.  
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5tud" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5tud" style="background-color:#fffaf0;"></div>
==See Also==
*[[5-hydroxytryptamine receptor 3D structures|5-hydroxytryptamine receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Lk3 transgenic mice]]
[[Category: Homo sapiens]]
[[Category: Basu, S]]
[[Category: Large Structures]]
[[Category: Boutet, S]]
[[Category: Mus musculus]]
[[Category: Cherezov, V]]
[[Category: Basu S]]
[[Category: Han, G W]]
[[Category: Boutet S]]
[[Category: Ishchenko, A]]
[[Category: Cherezov V]]
[[Category: James, D]]
[[Category: Han GW]]
[[Category: Kapoor, M]]
[[Category: Ishchenko A]]
[[Category: Katritch, V]]
[[Category: James D]]
[[Category: Liu, W]]
[[Category: Kapoor M]]
[[Category: Stevens, R C]]
[[Category: Katritch V]]
[[Category: Wacker, D]]
[[Category: Liu W]]
[[Category: Wang, D]]
[[Category: Stevens RC]]
[[Category: Weierstall, U]]
[[Category: Wacker D]]
[[Category: Zhang, A]]
[[Category: Wang D]]
[[Category: 7-tm]]
[[Category: Weierstall U]]
[[Category: Complex]]
[[Category: Zhang A]]
[[Category: Fab]]
[[Category: Gpcr]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/5tud"