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==NMR Structure of a Complex Containing the TFIIF Subunit RAP74 and the RNAP II CTD Phosphatase FCP1==
==NMR Structure of a Complex Containing the TFIIF Subunit RAP74 and the RNAP II CTD Phosphatase FCP1==
<StructureSection load='1onv' size='340' side='right' caption='[[1onv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1onv' size='340' side='right'caption='[[1onv]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1onv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ONV FirstGlance]. <br>
<table><tr><td colspan='2'>[[1onv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ONV FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1onv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1onv OCA], [http://pdbe.org/1onv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1onv RCSB], [http://www.ebi.ac.uk/pdbsum/1onv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1onv ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1onv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1onv OCA], [https://pdbe.org/1onv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1onv RCSB], [https://www.ebi.ac.uk/pdbsum/1onv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1onv ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/CTDP1_HUMAN CTDP1_HUMAN]] Defects in CTDP1 are a cause of congenital cataracts facial dysmorphism and neuropathy syndrome (CCFDN) [MIM:[http://omim.org/entry/604168 604168]]. CCFDN is an autosomal recessive developmental disorder that occurs in an endogamous group of Vlax Roma (Gypsies). The syndrome is characterized by a complex clinical phenotype with seemingly unrelated features involving multiple organs and systems. Developmental abnormalities include congenital cataracts and microcorneae, hypomyelination of the peripheral nervous system, impaired physical growth, delayed early motor and intellectual development, facial dysmorphism and hypogonadism. Central nervous system involvement, with cerebral and spinal cord atrophy, may be the result of disrupted development with superimposed degenerative changes. Affected individuals are prone to severe rhabdomyolysis after viral infections and to serious complications related to general anesthesia (such as pulmonary edema and epileptic seizures).<ref>PMID:14517542</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/T2FA_HUMAN T2FA_HUMAN]] TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.<ref>PMID:10428810</ref> [[http://www.uniprot.org/uniprot/CTDP1_HUMAN CTDP1_HUMAN]] Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.<ref>PMID:22692537</ref> 
[https://www.uniprot.org/uniprot/T2FA_HUMAN T2FA_HUMAN] TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.<ref>PMID:10428810</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1onv" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1onv" style="background-color:#fffaf0;"></div>
==See Also==
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Abbott, K L]]
[[Category: Large Structures]]
[[Category: Archambault, J]]
[[Category: Abbott KL]]
[[Category: Greenblatt, J]]
[[Category: Archambault J]]
[[Category: Kobor, M S]]
[[Category: Greenblatt J]]
[[Category: Legault, P]]
[[Category: Kobor MS]]
[[Category: Nguyen, B D]]
[[Category: Legault P]]
[[Category: Omichinski, J G]]
[[Category: Nguyen BD]]
[[Category: Potempa, K]]
[[Category: Omichinski JG]]
[[Category: Fcp1]]
[[Category: Potempa K]]
[[Category: Human general transcription factor tfiif]]
[[Category: Rap74]]
[[Category: Rna polymerase ii ctd phosphatase]]
[[Category: Tfiif-associating ctd phosphatase]]
[[Category: Transcription]]
[[Category: Transcription factor]]
Retrieved from "https://proteopedia.org/1onv"