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==Crystal structure of EHV4-TK complexed with TP5A==
==Crystal structure of EHV4-TK complexed with TP5A==
<StructureSection load='1p75' size='340' side='right' caption='[[1p75]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
<StructureSection load='1p75' size='340' side='right'caption='[[1p75]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1p75]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ehv-4 Ehv-4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P75 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1p75]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Equid_alphaherpesvirus_4 Equid alphaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P75 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p72|1p72]], [[1p6x|1p6x]], [[1p73|1p73]], [[1p7c|1p7c]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10331 EHV-4])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p75 OCA], [https://pdbe.org/1p75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p75 RCSB], [https://www.ebi.ac.uk/pdbsum/1p75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p75 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p75 OCA], [http://pdbe.org/1p75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p75 RCSB], [http://www.ebi.ac.uk/pdbsum/1p75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p75 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KITH_EHV4 KITH_EHV4]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).  
[https://www.uniprot.org/uniprot/KITH_EHV4 KITH_EHV4] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1p75" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1p75" style="background-color:#fffaf0;"></div>
==See Also==
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ehv-4]]
[[Category: Equid alphaherpesvirus 4]]
[[Category: Thymidine kinase]]
[[Category: Large Structures]]
[[Category: Gardberg, A]]
[[Category: Gardberg A]]
[[Category: Konrad, M]]
[[Category: Konrad M]]
[[Category: Lavie, A]]
[[Category: Lavie A]]
[[Category: Monnerjahn, C]]
[[Category: Monnerjahn C]]
[[Category: Shuvalova, L]]
[[Category: Shuvalova L]]
[[Category: Lid]]
[[Category: P-loop]]
[[Category: Transferase]]
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