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==T4 LYOSZYME CORE REPACKING MUTANT I100V/TA==
==T4 LYOSZYME CORE REPACKING MUTANT I100V/TA==
<StructureSection load='1p36' size='340' side='right' caption='[[1p36]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='1p36' size='340' side='right'caption='[[1p36]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1p36]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P36 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1p36]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P36 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p2l|1p2l]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p36 OCA], [https://pdbe.org/1p36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p36 RCSB], [https://www.ebi.ac.uk/pdbsum/1p36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p36 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p36 OCA], [http://pdbe.org/1p36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p36 RCSB], [http://www.ebi.ac.uk/pdbsum/1p36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p36 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.  
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1p36" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1p36" style="background-color:#fffaf0;"></div>
==See Also==
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bpt4]]
[[Category: Escherichia virus T4]]
[[Category: Lysozyme]]
[[Category: Large Structures]]
[[Category: Baase, W A]]
[[Category: Baase WA]]
[[Category: Datta, D]]
[[Category: Datta D]]
[[Category: Matthews, B W]]
[[Category: Matthews BW]]
[[Category: Mayo, S L]]
[[Category: Mayo SL]]
[[Category: Mooers, B H]]
[[Category: Mooers BH]]
[[Category: Zollars, E S]]
[[Category: Zollars ES]]
[[Category: Automated protein design]]
[[Category: Back revertant]]
[[Category: Core repacking]]
[[Category: Dead-end elimination theorem]]
[[Category: Designed core mutant]]
[[Category: Hydrolase]]
[[Category: Optimized rotamer combination]]
[[Category: Orbit]]
[[Category: Protein engineering]]
[[Category: Protein folding]]
[[Category: Protein stability]]
[[Category: Side-chain packing]]
[[Category: T4 lysozyme]]
Retrieved from "https://proteopedia.org/1p36"