Progesterone receptor: Difference between revisions
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<StructureSection load='2w8y' size=' | <StructureSection load='2w8y' size='350' side='right' caption='Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry [[2w8y]])' scene='78/780972/Cv/2'> | ||
== Function == | == Function == | ||
'''Progesterone receptor''' (PR) binds to DNA and inhibits transcription. | '''Progesterone receptor''' (PR) binds to DNA and inhibits transcription. It is [[Nuclear receptors|nuclear receptor]]. The inhibition terminates when progesterone binds to PR. The ovarian steroid progesterone which is essential for breast development and reproductive behavior, is mediated by PR<ref>PMID:19072517</ref>. | ||
See also [[Intracellular receptors]] | |||
== Relevance == | == Relevance == | ||
The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>. | The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy <ref>PMID:16234531</ref>. [[Mometasone]] is a potent agonist of PR<ref>PMID:15189034</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the binding site and several PR-RU486 interactions<ref>PMID:19372222</ref>. | The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the <scene name='78/780972/Cv/4'>binding site and several PR-RU486 interactions</scene><ref>PMID:19372222</ref>. Water molecules are shown as red spheres. <scene name='89/895670/Cv/8'>Human progesterone receptor ligand-binding domain bound with progesterone</scene> ([[1a28]]). | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of progesterone receptor == | == 3D Structures of progesterone receptor == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
* Progesterone receptor residues 1-125 | |||
**[[1ejf]] – hPR - human<br /> | |||
* Progesterone receptor residues 72-195 | |||
**[[4x8y]] – hPR<br /> | |||
* Progesterone receptor DNA-binding domain residues 399-476 | * Progesterone receptor DNA-binding domain residues 399-476 | ||
**[[2c7a]] – hPR DBD + DNA | **[[2c7a]] – hPR DBD + DNA<br /> | ||
* Progesterone receptor ligand-binding domain residues 673-933 | * Progesterone receptor ligand-binding domain residues 673-933 | ||
Latest revision as of 09:29, 18 January 2024
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3D Structures of progesterone receptor
Updated on 18-January-2024
