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==Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA==
==Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA==
<StructureSection load='5tih' size='340' side='right' caption='[[5tih]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
<StructureSection load='5tih' size='340' side='right'caption='[[5tih]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5tih]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TIH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5tih]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TIH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tik|5tik]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF3D7_0423800 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tih OCA], [https://pdbe.org/5tih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tih RCSB], [https://www.ebi.ac.uk/pdbsum/5tih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tih ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tih OCA], [http://pdbe.org/5tih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tih RCSB], [http://www.ebi.ac.uk/pdbsum/5tih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tih ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYRPA_PLAF7 CYRPA_PLAF7] Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:22593616, PubMed:25583518, PubMed:27374406, PubMed:28195038, PubMed:28195530). Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes (PubMed:25583518, PubMed:28186186, PubMed:28195038, PubMed:28195530, PubMed:30542156). This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte (PubMed:27374406, PubMed:28186186, PubMed:30542156).<ref>PMID:22593616</ref> <ref>PMID:25583518</ref> <ref>PMID:27374406</ref> <ref>PMID:28186186</ref> <ref>PMID:28195038</ref> <ref>PMID:28195530</ref> <ref>PMID:30542156</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5tih" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5tih" style="background-color:#fffaf0;"></div>
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Plaf7]]
[[Category: Mus musculus]]
[[Category: Chen, L]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Cowman, A F]]
[[Category: Chen L]]
[[Category: Goddard-Borger, E]]
[[Category: Cowman AF]]
[[Category: Lawrence, M C]]
[[Category: Goddard-Borger E]]
[[Category: Thompson, J K]]
[[Category: Lawrence MC]]
[[Category: Wang, W]]
[[Category: Thompson JK]]
[[Category: Xu, Y]]
[[Category: Wang W]]
[[Category: Immune system]]
[[Category: Xu Y]]
[[Category: Plasmodium falciparum cyrpa inhibitory antibody]]
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