5tik: Difference between revisions
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==Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA== | ==Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA== | ||
<StructureSection load='5tik' size='340' side='right' caption='[[5tik]], [[Resolution|resolution]] 3.09Å' scene=''> | <StructureSection load='5tik' size='340' side='right'caption='[[5tik]], [[Resolution|resolution]] 3.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5tik]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5tik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TIK FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.09Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tik OCA], [https://pdbe.org/5tik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tik RCSB], [https://www.ebi.ac.uk/pdbsum/5tik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tik ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CYRPA_PLAF7 CYRPA_PLAF7] Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:22593616, PubMed:25583518, PubMed:27374406, PubMed:28195038, PubMed:28195530). Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes (PubMed:25583518, PubMed:28186186, PubMed:28195038, PubMed:28195530, PubMed:30542156). This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte (PubMed:27374406, PubMed:28186186, PubMed:30542156).<ref>PMID:22593616</ref> <ref>PMID:25583518</ref> <ref>PMID:27374406</ref> <ref>PMID:28186186</ref> <ref>PMID:28195038</ref> <ref>PMID:28195530</ref> <ref>PMID:30542156</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Plasmodium falciparum 3D7]] | ||
[[Category: Cowman | [[Category: Chen L]] | ||
[[Category: Goddard-Borger | [[Category: Cowman AF]] | ||
[[Category: Lawrence | [[Category: Goddard-Borger E]] | ||
[[Category: Thompson | [[Category: Lawrence MC]] | ||
[[Category: Wang | [[Category: Thompson JK]] | ||
[[Category: Xu | [[Category: Wang W]] | ||
[[Category: Xu Y]] | |||
