Sandbox Reserved 1410: Difference between revisions
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==COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT== | ==COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT== | ||
<Structure load='1aoi' size='500' frame='true' align='right' caption='Structure of COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT' scene='' /> | <Structure load='1aoi' size='500' frame='true' align='right' caption='Structure of COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT' scene='' /> | ||
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a | COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome. | ||
== Organism of Origin == | == Organism of Origin == | ||
This protein comes form the African Clawed Frog (''Xenopus Laevis''). [[Image: | This protein comes form the African Clawed Frog (''Xenopus Laevis''). [[Image:Africanclawedfrog.jpg|thumb|left|African Clawed Frog]] | ||
This frog can swim really fast in all directions. | This frog can swim really fast in all directions. | ||
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COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome. | COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome. | ||
There are a total of 418 <scene name='77/777730/1aoi_not_dna/2'>amino acids</scene> which make up four different histone structures on the inside (Histone H3.3C, H4, H2A type 1, and H2B 1.1). | There are a total of 418 <scene name='77/777730/1aoi_not_dna/2'>amino acids</scene> which make up four different histone structures on the inside (Histone H3.3C, H4, H2A type 1, and H2B 1.1). The N-terminus tails of H3 and H2B allow the histone complex to interact with other histone complexes. | ||
The <scene name='77/777730/1aoi_dna_only/1'>DNA</scene> is found on the outside. The DNA chains are 146 nucleotides long. | The <scene name='77/777730/1aoi_dna_only/1'>DNA</scene> is found on the outside. The DNA chains are 146 nucleotides long. | ||
There are also 6 manganese (II) ion <scene name='77/777730/1aoi_ligands/1'>ligands</scene> in this protein. | There are also 6 manganese (II) ion <scene name='77/777730/1aoi_ligands/1'>ligands</scene> in this protein. They are all located on the DNA. | ||
Fun fact: The DNA in this protein is palindromic. | Fun fact: The DNA in this protein is palindromic. | ||
== Function == | == Function == | ||
The hydrogen bond interactions between the histone structures and the DNA makes this molecule allow for this protein to be involved in DNA packaging, binding, and transcription. | |||
== Significance == | == Significance == | ||
This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome. | This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome. This resulting complex also prevents unwanted binding and transcription of DNA because it is so tightly wound together. | ||
== References == | == References == | ||
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https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310 | https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310 | ||
https://www.nature.com/articles/38444 | |||
