5qfa: Difference between revisions
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==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000752b== | |||
<StructureSection load='5qfa' size='340' side='right'caption='[[5qfa]], [[Resolution|resolution]] 1.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QFA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.742Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JNG:[(4-chlorophenyl)sulfanyl]acetic+acid'>JNG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qfa OCA], [https://pdbe.org/5qfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qfa RCSB], [https://www.ebi.ac.uk/pdbsum/5qfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qfa ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
==See Also== | |||
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Biel | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Biel JT]] | ||
[[Category: | [[Category: Brandao-Neto J]] | ||
[[Category: | [[Category: Fraser JS]] | ||
[[Category: | [[Category: Hill ZB]] | ||
[[Category: Von Delft | [[Category: Kang E]] | ||
[[Category: Keedy DA]] | |||
[[Category: Rettenmaier TJ]] | |||
[[Category: Wells JA]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 08:53, 7 February 2024
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000752b
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