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==Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase==
==Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase==
<StructureSection load='2iu3' size='340' side='right' caption='[[2iu3]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='2iu3' size='340' side='right'caption='[[2iu3]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2iu3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IU3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2iu3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IU3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=203:1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE+2,2-DIOXIDE'>203</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g8m|1g8m]], [[1m9n|1m9n]], [[1oz0|1oz0]], [[1thz|1thz]], [[2iu0|2iu0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=203:1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE+2,2-DIOXIDE'>203</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iu3 OCA], [http://pdbe.org/2iu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2iu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iu3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iu3 OCA], [https://pdbe.org/2iu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iu3 RCSB], [https://www.ebi.ac.uk/pdbsum/2iu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iu3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PUR9_CHICK PUR9_CHICK]] Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.<ref>PMID:12501179</ref>
[https://www.uniprot.org/uniprot/PUR9_CHICK PUR9_CHICK] Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.<ref>PMID:12501179</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2iu3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2iu3" style="background-color:#fffaf0;"></div>
==See Also==
*[[Bifunctional purine biosynthesis protein PURH|Bifunctional purine biosynthesis protein PURH]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Amore, K]]
[[Category: Large Structures]]
[[Category: Beardsley, G P]]
[[Category: Amore K]]
[[Category: Boger, D L]]
[[Category: Beardsley GP]]
[[Category: Chong, Y]]
[[Category: Boger DL]]
[[Category: Hwang, I]]
[[Category: Chong Y]]
[[Category: Li, C]]
[[Category: D'Onofrio A]]
[[Category: Olson, A J]]
[[Category: Hwang I]]
[[Category: Onofrio, A D]]
[[Category: Li C]]
[[Category: Wilson, I A]]
[[Category: Olson AJ]]
[[Category: Xu, L]]
[[Category: Wilson IA]]
[[Category: Atic]]
[[Category: Xu L]]
[[Category: Hydrolase]]
[[Category: Impch]]
[[Category: Inhibitor]]
[[Category: Multifunctional enzyme]]
[[Category: Purine biosynthesis]]
[[Category: Structure-base]]
[[Category: Transferase]]
[[Category: Transition state analogue]]
Retrieved from "https://proteopedia.org/2iu3"