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==NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA5==
==NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA5==
<StructureSection load='2wij' size='340' side='right' caption='[[2wij]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2wij' size='340' side='right'caption='[[2wij]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wij]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WIJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WIJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TN7:ETHYL+HYDROGEN+ETHYLAMIDOPHOSPHATE'>TN7</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ehq|1ehq]], [[2j4c|2j4c]], [[1p0q|1p0q]], [[1kcj|1kcj]], [[1p0p|1p0p]], [[1xlu|1xlu]], [[1xlv|1xlv]], [[1eho|1eho]], [[1p0m|1p0m]], [[1xlw|1xlw]], [[1p0i|1p0i]], [[2wid|2wid]], [[2wif|2wif]], [[2wig|2wig]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TN7:ETHYL+HYDROGEN+ETHYLAMIDOPHOSPHATE'>TN7</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wij OCA], [https://pdbe.org/2wij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wij RCSB], [https://www.ebi.ac.uk/pdbsum/2wij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wij ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wij OCA], [http://pdbe.org/2wij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wij RCSB], [http://www.ebi.ac.uk/pdbsum/2wij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wij ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.  
[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2wij" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2wij" style="background-color:#fffaf0;"></div>
==See Also==
*[[Butyrylcholinesterase 3D structures|Butyrylcholinesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cholinesterase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Aurbek, N]]
[[Category: Aurbek N]]
[[Category: Carletti, E]]
[[Category: Carletti E]]
[[Category: Fontecilla, J]]
[[Category: Fontecilla J]]
[[Category: Gillon, E]]
[[Category: Gillon E]]
[[Category: Loiodice, M]]
[[Category: Loiodice M]]
[[Category: Masson, P]]
[[Category: Masson P]]
[[Category: Nachon, F]]
[[Category: Nachon F]]
[[Category: Nicolet, Y]]
[[Category: Nicolet Y]]
[[Category: Thiermann, H]]
[[Category: Thiermann H]]
[[Category: Worek, F]]
[[Category: Worek F]]
[[Category: Aging]]
[[Category: Disease mutation]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Inhibition]]
[[Category: Polymorphism]]
[[Category: Serine esterase]]
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