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==Carbon Sulfoxide lyase, Egt2 in the Ergothioneine biosynthesis pathway==
==Crystal structure of Carbon Sulfoxide lyase, Egt2 Y134F with sulfenic acid intermediate==
<StructureSection load='5v12' size='340' side='right' caption='[[5v12]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='5v12' size='340' side='right'caption='[[5v12]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5v12]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V12 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5v12]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa_OR74A Neurospora crassa OR74A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V12 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8QJ:(2~{S})-3-(2-oxidanylsulfanyl-1~{H}-imidazol-4-yl)-2-(trimethyl-$l^{4}-azanyl)propanoic+acid'>8QJ</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.451&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=EXA:'>EXA</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QJ:(2~{S})-3-(2-oxidanylsulfanyl-1~{H}-imidazol-4-yl)-2-(trimethyl-$l^{4}-azanyl)propanoic+acid'>8QJ</scene>, <scene name='pdbligand=EXA:N~6~-[(R)-[(E)-(1-carboxyethylidene)amino]{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl]-L-lysine'>EXA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v12 OCA], [http://pdbe.org/5v12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v12 RCSB], [http://www.ebi.ac.uk/pdbsum/5v12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v12 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v12 OCA], [https://pdbe.org/5v12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v12 RCSB], [https://www.ebi.ac.uk/pdbsum/5v12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v12 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EGT2_NEUCR EGT2_NEUCR]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Irani, S]]
[[Category: Large Structures]]
[[Category: Zhang, Y]]
[[Category: Neurospora crassa OR74A]]
[[Category: C-s lyase]]
[[Category: Irani S]]
[[Category: Lyase]]
[[Category: Zhang Y]]
[[Category: Plp dependent]]

Latest revision as of 07:28, 1 May 2024

Crystal structure of Carbon Sulfoxide lyase, Egt2 Y134F with sulfenic acid intermediate

5v12, resolution 2.45Å

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