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==Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9==
==Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9==
<StructureSection load='5xij' size='340' side='right' caption='[[5xij]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5xij' size='340' side='right'caption='[[5xij]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xij]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XIJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xij]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_ME49 Toxoplasma gondii ME49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XIJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=873:3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one'>873</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xif|5xif]], [[5xig|5xig]], [[5xih|5xih]], [[5xii|5xii]], [[5xik|5xik]], [[5xil|5xil]], [[5xio|5xio]], [[5xip|5xip]], [[5xiq|5xiq]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=873:3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one'>873</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xij OCA], [https://pdbe.org/5xij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xij RCSB], [https://www.ebi.ac.uk/pdbsum/5xij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xij ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xij OCA], [http://pdbe.org/5xij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xij RCSB], [http://www.ebi.ac.uk/pdbsum/5xij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xij ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S8G8I1_TOXGM S8G8I1_TOXGM]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5xij" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5xij" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Proline--tRNA ligase]]
[[Category: Large Structures]]
[[Category: Jain, V]]
[[Category: Toxoplasma gondii ME49]]
[[Category: Manickam, Y]]
[[Category: Jain V]]
[[Category: Sharma, A]]
[[Category: Manickam Y]]
[[Category: Infectious disease]]
[[Category: Sharma A]]
[[Category: Inhibitor]]
[[Category: Ligase]]
[[Category: Pr]]
[[Category: Protein translation]]
[[Category: Synthetase]]
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