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==NMR structure of yeast oligosaccharyltransferase subunit Ost4p==
==NMR structure of yeast oligosaccharyltransferase subunit Ost4p==
<StructureSection load='1rkl' size='340' side='right' caption='[[1rkl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1rkl' size='340' side='right'caption='[[1rkl]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1rkl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RKL FirstGlance]. <br>
<table><tr><td colspan='2'>[[1rkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RKL FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dolichyl-diphosphooligosaccharide--protein_glycotransferase Dolichyl-diphosphooligosaccharide--protein glycotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.18 2.4.99.18] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rkl OCA], [http://pdbe.org/1rkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rkl RCSB], [http://www.ebi.ac.uk/pdbsum/1rkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rkl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rkl OCA], [https://pdbe.org/1rkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rkl RCSB], [https://www.ebi.ac.uk/pdbsum/1rkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rkl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OST4_YEAST OST4_YEAST]] Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. OST4 is required for recruitment of OST3 or OST6 to the OST complex. It is essential for cell growth at 37 but not at 25 degrees Celsius.  
[https://www.uniprot.org/uniprot/OST4_YEAST OST4_YEAST] Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. OST4 is required for recruitment of OST3 or OST6 to the OST complex. It is essential for cell growth at 37 but not at 25 degrees Celsius.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 1rkl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1rkl" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dolichyl-diphosphooligosaccharide--protein glycotransferase]]
[[Category: Large Structures]]
[[Category: Lennarz, W J]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Mohanty, S]]
[[Category: Lennarz WJ]]
[[Category: Zubkov, S]]
[[Category: Mohanty S]]
[[Category: Membrane protein]]
[[Category: Zubkov S]]
[[Category: Transferase]]
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