5ypr: Difference between revisions
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==Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor== | ==Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor== | ||
<StructureSection load='5ypr' size='340' side='right' caption='[[5ypr]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='5ypr' size='340' side='right'caption='[[5ypr]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ypr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YPR OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5ypr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YPR FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.349Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ypr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ypr OCA], [https://pdbe.org/5ypr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ypr RCSB], [https://www.ebi.ac.uk/pdbsum/5ypr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ypr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 18: | Line 18: | ||
</div> | </div> | ||
<div class="pdbe-citations 5ypr" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5ypr" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Shang Y]] | ||
[[Category: | [[Category: Weng Z]] | ||
[[Category: | [[Category: Zhang M]] | ||
[[Category: | [[Category: Zhou Q]] | ||
[[Category: | [[Category: Zhu J]] | ||
[[Category: Zhu R]] | |||
