1szv: Difference between revisions

<StructureSection load='1szv' size='340' side='right'caption='[[1szv]]' scene=''>

<table><tr><td colspan='2'>[[1szv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZV FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1szv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szv OCA], [https://pdbe.org/1szv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1szv RCSB], [https://www.ebi.ac.uk/pdbsum/1szv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1szv ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/LTOR2_MOUSE LTOR2_MOUSE] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:15263099</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Farooq A]]

[[Category: Qian C]]

[[Category: Wang X]]

[[Category: Zeng L]]

[[Category: Zhang Q]]

[[Category: Zhou MM]]