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[[Image:2frv.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURE OF THE OXIDIZED FORM OF NI-FE HYDROGENASE==
|PDB= 2frv |SIZE=350|CAPTION= <scene name='initialview01'>2frv</scene>, resolution 2.54&Aring;
<StructureSection load='2frv' size='340' side='right'caption='[[2frv]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
|SITE= <scene name='pdbsite=ACT:Ni-Fe+Active+Site'>ACT</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FCO:CARBONMONOXIDE-(DICYANO)+IRON'>FCO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
<table><tr><td colspan='2'>[[2frv]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Megalodesulfovibrio_gigas Megalodesulfovibrio gigas]. The March 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hydrogenase''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_3 10.2210/rcsb_pdb/mom_2009_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FRV FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferredoxin_hydrogenase Ferredoxin hydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.12.7.2 1.12.7.2] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FCO:CARBONMONOXIDE-(DICYANO)+IRON'>FCO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2frv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2frv OCA], [https://pdbe.org/2frv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2frv RCSB], [https://www.ebi.ac.uk/pdbsum/2frv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2frv ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2frv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2frv OCA], [http://www.ebi.ac.uk/pdbsum/2frv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2frv RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PHNS_MEGGA PHNS_MEGGA]
 
== Evolutionary Conservation ==
'''CRYSTAL STRUCTURE OF THE OXIDIZED FORM OF NI-FE HYDROGENASE'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/2frv_consurf.spt"</scriptWhenChecked>
2FRV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRV OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Desulfovibrio gigas]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Ferredoxin hydrogenase]]
  </jmolCheckbox>
[[Category: Protein complex]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2frv ConSurf].
[[Category: Fontecilla-Camps, J C.]]
<div style="clear:both"></div>
[[Category: Frey, M.]]
__TOC__
[[Category: Volbeda, A.]]
</StructureSection>
[[Category: ni-fe hydrogenase]]
[[Category: Hydrogenase]]
[[Category: oxidoreductase]]
[[Category: Large Structures]]
 
[[Category: Megalodesulfovibrio gigas]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:06:52 2008''
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Fontecilla-Camps JC]]
[[Category: Frey M]]
[[Category: Volbeda A]]
Retrieved from "https://proteopedia.org/2frv"