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[[Image:2ftx.gif|left|200px]]


{{Structure
==Crystal structure of the yeast kinetochore Spc24/Spc25 globular domain==
|PDB= 2ftx |SIZE=350|CAPTION= <scene name='initialview01'>2ftx</scene>, resolution 1.90&Aring;
<StructureSection load='2ftx' size='340' side='right'caption='[[2ftx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[2ftx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FTX FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|GENE= YER018C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), YMR117C, YM9718.16C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YER018C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), YMR117C, YM9718.16C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
|RELATEDENTRY=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ftx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftx OCA], [https://pdbe.org/2ftx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ftx RCSB], [https://www.ebi.ac.uk/pdbsum/2ftx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ftx ProSAT]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ftx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftx OCA], [http://www.ebi.ac.uk/pdbsum/2ftx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ftx RCSB]</span>
</table>
}}
== Function ==
 
[[https://www.uniprot.org/uniprot/SPC25_YEAST SPC25_YEAST]] Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.<ref>PMID:11266451</ref> <ref>PMID:12514103</ref>  [[https://www.uniprot.org/uniprot/SPC24_YEAST SPC24_YEAST]] Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.<ref>PMID:11266451</ref> <ref>PMID:11952896</ref> <ref>PMID:12514103</ref> 
'''Crystal structure of the yeast kinetochore Spc24/Spc25 globular domain'''
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==About this Structure==
  <jmolCheckbox>
2FTX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTX OCA].  
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ftx_consurf.spt"</scriptWhenChecked>
[[Category: Protein complex]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Saccharomyces cerevisiae]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Harrison, S C.]]
  </jmolCheckbox>
[[Category: Wei, R R.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ftx ConSurf].
[[Category: alpha-beta]]
<div style="clear:both"></div>
[[Category: coiled-coil]]
== References ==
[[Category: complex]]
<references/>
 
__TOC__
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:07:38 2008''
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Harrison, S C]]
[[Category: Wei, R R]]
[[Category: Alpha-beta]]
[[Category: Coiled-coil]]
[[Category: Complex]]
[[Category: Protein binding]]
[[Category: Structural protein]]
Retrieved from "https://proteopedia.org/2ftx"