6g03: Difference between revisions
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The | ==NMR Solution Structure of yeast TSR2(1-152)== | ||
<StructureSection load='6g03' size='340' side='right'caption='[[6g03]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G03 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g03 OCA], [https://pdbe.org/6g03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g03 RCSB], [https://www.ebi.ac.uk/pdbsum/6g03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g03 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TSR2_YEAST TSR2_YEAST] Required for 20S pre-rRNA processing.<ref>PMID:12837249</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Disordered extensions at the termini and short internal insertions distinguish eukaryotic ribosomal proteins (r-proteins) from their anucleated archaeal counterparts. Here, we report an NMR structure of such a eukaryotic-specific segment (ESS) in the r-protein eS26 in complex with the escortin Tsr2. The structure reveals how ESS attracts Tsr2 specifically to importin:eS26 complexes entering the nucleus in order to trigger non-canonical RanGTP-independent disassembly. Tsr2 then sequesters the released eS26 and prevents rebinding to the importin, providing an alternative allosteric mechanism to terminate the process of nuclear import. Notably, a Diamond-Blackfan anemia-associated Tsr2 mutant protein is impaired in binding to ESS, unveiling a critical role for this interaction in human hematopoiesis. We propose that eS26-ESS and Tsr2 are components of a nuclear sorting system that co-evolved with the emergence of the nucleocytoplasmic barrier and transport carriers. | |||
Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2.,Schutz S, Michel E, Damberger FF, Oplova M, Pena C, Leitner A, Aebersold R, Allain FH, Panse VG Nat Commun. 2018 Sep 10;9(1):3669. doi: 10.1038/s41467-018-06160-x. PMID:30201955<ref>PMID:30201955</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6g03" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Allain FH-T]] | |||
[[Category: Damberger FF]] | |||
[[Category: Michel E]] | |||
[[Category: Panse VG]] | |||
[[Category: Schuetz S]] | |||
Latest revision as of 06:05, 19 June 2024
NMR Solution Structure of yeast TSR2(1-152)
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