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==Complex of Hook Domain with a Dynein Light Intermediate Chain Peptide==
==Complex of Hook Domain with a Dynein Light Intermediate Chain Peptide==
<StructureSection load='6b9h' size='340' side='right' caption='[[6b9h]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='6b9h' size='340' side='right'caption='[[6b9h]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6b9h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B9H FirstGlance]. <br>
<table><tr><td colspan='2'>[[6b9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B9H FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b9h OCA], [http://pdbe.org/6b9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b9h RCSB], [http://www.ebi.ac.uk/pdbsum/6b9h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b9h ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b9h OCA], [https://pdbe.org/6b9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b9h RCSB], [https://www.ebi.ac.uk/pdbsum/6b9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b9h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HOOK3_HUMAN HOOK3_HUMAN]] Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.<ref>PMID:11238449</ref> <ref>PMID:17237231</ref> <ref>PMID:18799622</ref> [[http://www.uniprot.org/uniprot/DC1L1_HUMAN DC1L1_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.<ref>PMID:19229290</ref> 
[https://www.uniprot.org/uniprot/HOOK3_HUMAN HOOK3_HUMAN] Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.<ref>PMID:11238449</ref> <ref>PMID:17237231</ref> <ref>PMID:18799622</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6b9h" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6b9h" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dynein 3D structures|Dynein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dominguez, R]]
[[Category: Homo sapiens]]
[[Category: Lee, I G]]
[[Category: Large Structures]]
[[Category: Dynactin]]
[[Category: Dominguez R]]
[[Category: Dynein]]
[[Category: Lee IG]]
[[Category: Effector]]
[[Category: Hook]]
[[Category: Protein transport-motor protein complex]]
Retrieved from "https://proteopedia.org/6b9h"