1tq4: Difference between revisions

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==Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases==
==Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases==
<StructureSection load='1tq4' size='340' side='right' caption='[[1tq4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='1tq4' size='340' side='right'caption='[[1tq4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1tq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQ4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1tq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQ4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f5n|1f5n]], [[1dg3|1dg3]], [[1tqd|1tqd]], [[1tpz|1tpz]], [[1tq2|1tq2]], [[1tq6|1tq6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IIGP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq4 OCA], [https://pdbe.org/1tq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tq4 RCSB], [https://www.ebi.ac.uk/pdbsum/1tq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq4 OCA], [http://pdbe.org/1tq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tq4 RCSB], [http://www.ebi.ac.uk/pdbsum/1tq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>
[https://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Ghosh, A]]
[[Category: Mus musculus]]
[[Category: Herrmann, C]]
[[Category: Ghosh A]]
[[Category: Howard, J]]
[[Category: Herrmann C]]
[[Category: Uthaiah, R]]
[[Category: Howard J]]
[[Category: Wolf, E]]
[[Category: Uthaiah R]]
[[Category: Dimer]]
[[Category: Wolf E]]
[[Category: Gtpase]]
[[Category: Immunology]]
[[Category: Interferon gamma]]
[[Category: Signaling protein]]
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