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==Structure of the cyclopropane synthase MmaA2 from Mycobacterium tuberculosis==
==Structure of the cyclopropane synthase MmaA2 from Mycobacterium tuberculosis==
<StructureSection load='1tpy' size='340' side='right' caption='[[1tpy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1tpy' size='340' side='right'caption='[[1tpy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1tpy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TPY FirstGlance]. <br>
<table><tr><td colspan='2'>[[1tpy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TPY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16A:CETYL-TRIMETHYL-AMMONIUM'>16A</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mmaA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16A:CETYL-TRIMETHYL-AMMONIUM'>16A</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclopropane-fatty-acyl-phospholipid_synthase Cyclopropane-fatty-acyl-phospholipid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.79 2.1.1.79] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpy OCA], [https://pdbe.org/1tpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tpy RCSB], [https://www.ebi.ac.uk/pdbsum/1tpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpy OCA], [http://pdbe.org/1tpy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tpy RCSB], [http://www.ebi.ac.uk/pdbsum/1tpy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MMAA2_MYCTU MMAA2_MYCTU]] Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. MmaA2 also catalyzes the biosynthesis of the cis-cyclopropanated methoxymycolates. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.<ref>PMID:12502719</ref> <ref>PMID:20472794</ref>
[https://www.uniprot.org/uniprot/MMAA2_MYCTU MMAA2_MYCTU] Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. MmaA2 also catalyzes the biosynthesis of the cis-cyclopropanated methoxymycolates. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.<ref>PMID:12502719</ref> <ref>PMID:20472794</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]
[[Category: Large Structures]]
[[Category: Sacchettini, J C]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Smith, C V]]
[[Category: Sacchettini JC]]
[[Category: Cyclopropane synthase]]
[[Category: Smith CV]]
[[Category: Methyltransferase]]
[[Category: Mycolic acid]]
[[Category: Sam-dependent]]
[[Category: Transferase]]
[[Category: Tuberculosis]]

Latest revision as of 06:32, 23 August 2023

Structure of the cyclopropane synthase MmaA2 from Mycobacterium tuberculosis

1tpy, resolution 2.20Å

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