2g02: Difference between revisions

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[[Image:2g02.gif|left|200px]]


{{Structure
==Nisin cyclase==
|PDB= 2g02 |SIZE=350|CAPTION= <scene name='initialview01'>2g02</scene>, resolution 2.50&Aring;
<StructureSection load='2g02' size='340' side='right'caption='[[2g02]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[2g02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G02 FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE= nisC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1360 Lactococcus lactis subsp. lactis])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g02 OCA], [https://pdbe.org/2g02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g02 RCSB], [https://www.ebi.ac.uk/pdbsum/2g02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g02 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2g0d|2G0D]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g02 OCA], [http://www.ebi.ac.uk/pdbsum/2g02 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g02 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/NISC_LACLL NISC_LACLL] Could be implicated in the processing or the export process of the nisin lantibiotic.
 
== Evolutionary Conservation ==
'''Nisin cyclase'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g02_consurf.spt"</scriptWhenChecked>
Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2G02 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G02 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g02 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16527981 16527981]
</StructureSection>
[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Nair, S K.]]
[[Category: Nair SK]]
[[Category: alpha barrel]]
[[Category: alpha toroid]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:10:00 2008''
Retrieved from "https://proteopedia.org/2g02"