6cp9: Difference between revisions

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'''Unreleased structure'''


The entry 6cp9 is ON HOLD  until Paper Publication
==Contact-dependent growth inhibition toxin - immunity protein complex from Klebsiella pneumoniae 342==
<StructureSection load='6cp9' size='340' side='right'caption='[[6cp9]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6cp9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Klep3 Klep3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CP9 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KPK_4110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=507522 KLEP3])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cp9 OCA], [http://pdbe.org/6cp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cp9 RCSB], [http://www.ebi.ac.uk/pdbsum/6cp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cp9 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Contact-dependent growth inhibition (CDI) is a form of interbacterial competition mediated by CdiB-CdiA two-partner secretion systems. CdiA effector proteins carry polymorphic C-terminal toxin domains (CdiA-CT), which are neutralized by specific CdiI immunity proteins to prevent self-inhibition. Here, we present the crystal structures of CdiA-CTCdiI complexes from Klebsiella pneumoniae 342 and Escherichia coli 3006. The toxins adopt related folds that resemble the ribonuclease domain of colicin D, and both are isoacceptor-specific tRNases that cleave the acceptor stem of deacylated tRNAGAU(Ile). Although the toxins are similar in structure and substrate specificity, CdiA-CT(Kp342) activity requires translation factors EF-Tu and EF-Ts, whereas CdiA-CT(EC3006) is intrinsically active. Furthermore, the corresponding immunity proteins are unrelated in sequence and structure. CdiI(Kp342) forms a dimeric beta sandwich, whereas CdiI(EC3006) is an alpha-solenoid monomer. Given that toxin-immunity genes co-evolve as linked pairs, these observations suggest that the similarities in toxin structure and activity reflect functional convergence.


Authors: Michalska, K., Stols, L., Eschenfeldt, W., Hayes, C.S., Goulding, C.W., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.,Gucinski GC, Michalska K, Garza-Sanchez F, Eschenfeldt WH, Stols L, Nguyen JY, Goulding CW, Joachimiak A, Hayes CS Structure. 2019 Sep 6. pii: S0969-2126(19)30281-3. doi:, 10.1016/j.str.2019.08.010. PMID:31515004<ref>PMID:31515004</ref>


Description: Contact-dependent growth inhibition toxin -immunity protein complex from Klebsiella pneumoniae 342
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 6cp9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Klep3]]
[[Category: Large Structures]]
[[Category: Eschenfeldt, W]]
[[Category: Goulding, C W]]
[[Category: Hayes, C S]]
[[Category: Joachimiak, A]]
[[Category: Structural genomic]]
[[Category: Michalska, K]]
[[Category: Michalska, K]]
[[Category: Goulding, C.W]]
[[Category: Midwest Center For Structural Genomics (Mcsg), Structure-Function Analysis Of Polymorphic Cdi Toxin-Immunity Protein Complexes (Uc4cdi)]]
[[Category: Stols, L]]
[[Category: Stols, L]]
[[Category: Hayes, C.S]]
[[Category: UC4CDI, Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes]]
[[Category: Joachimiak, A]]
[[Category: Mcsg]]
[[Category: Eschenfeldt, W]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Rnase]]
[[Category: Structure-function analysis of polymorphic cdi toxin-immunity protein complex]]
[[Category: Toxin]]
[[Category: Toxin-antitoxin complex]]
[[Category: Uc4cdi]]

Latest revision as of 07:49, 23 October 2019

Contact-dependent growth inhibition toxin - immunity protein complex from Klebsiella pneumoniae 342

6cp9, resolution 2.55Å

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