6g0d: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 6g0d is ~~ON HOLD~~

==BRD4 (BD1) in complex with APSC-derived ligands (e.g. LY294002)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6g0d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G0D FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LY2:2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE'>LY2</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g0d OCA], [http://pdbe.org/6g0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g0d RCSB], [http://www.ebi.ac.uk/pdbsum/6g0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g0d ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Humbeck, L]]

[[Category: Pretzel, J]]

[[Category: Brd4]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6g0d is ON HOLD
+==BRD4 (BD1) in complex with APSC-derived ligands (e.g. LY294002)==
+<StructureSection load='6g0d' size='340' side='right'caption='[[6g0d]], [[Resolution|resolution]] 1.31&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6g0d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G0D FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LY2:2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE'>LY2</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g0d OCA], [http://pdbe.org/6g0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g0d RCSB], [http://www.ebi.ac.uk/pdbsum/6g0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g0d ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Humbeck, L]]
+[[Category: Pretzel, J]]
+[[Category: Brd4]]
+[[Category: Transcription]]