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==The crystal structure of Staphylococcus aureus CntA in complex with staphylopine and cobalt==
==The crystal structure of Staphylococcus aureus CntA in complex with staphylopine and cobalt==
<StructureSection load='5yhe' size='340' side='right' caption='[[5yhe]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
<StructureSection load='5yhe' size='340' side='right'caption='[[5yhe]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5yhe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YHE FirstGlance]. <br>
<table><tr><td colspan='2'>[[5yhe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YHE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8UX:(2~{S})-4-[[(2~{R})-3-(1~{H}-imidazol-4-yl)-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-[[(2~{S})-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]butanoic+acid'>8UX</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.465&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhe OCA], [http://pdbe.org/5yhe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yhe RCSB], [http://www.ebi.ac.uk/pdbsum/5yhe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhe ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8UX:(2~{S})-4-[[(2~{R})-3-(1~{H}-imidazol-4-yl)-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-[[(2~{S})-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]butanoic+acid'>8UX</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhe OCA], [https://pdbe.org/5yhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yhe RCSB], [https://www.ebi.ac.uk/pdbsum/5yhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CNTA_STAA8 CNTA_STAA8] Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Binds the metal via the metallophore StP, and transfers the StP-metal complex to the membrane-bound permease (PubMed:23279021, PubMed:29581261). Binds one molecule of StP/metal. Binds StP/Co(2+) and StP/Ni(2+) tighter than StP/Zn(2+) (PubMed:29581261). Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro (PubMed:23279021).<ref>PMID:23279021</ref> <ref>PMID:29581261</ref>
==See Also==
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ji, Q]]
[[Category: Large Structures]]
[[Category: Song, L]]
[[Category: Staphylococcus aureus]]
[[Category: Metal binding protein]]
[[Category: Ji Q]]
[[Category: Receptor]]
[[Category: Song L]]
Retrieved from "https://proteopedia.org/5yhe"