6g3t: Difference between revisions
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New page: '''Unreleased structure''' The entry 6g3t is ON HOLD until Paper Publication Authors: Boettcher, J., Muellauer, B.J., Weiss-Puxbaum, A., Zoephel, A. Description: X-ray structure of NSD... |
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==X-ray structure of NSD3-PWWP1== | |||
<StructureSection load='6g3t' size='340' side='right'caption='[[6g3t]], [[Resolution|resolution]] 2.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g3t]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G3T FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g24|6g24]], [[6g25|6g25]], [[6g27|6g27]], [[6g29|6g29]], [[6g2b|6g2b]], [[6g2c|6g2c]], [[6g2e|6g2e]], [[6g2f|6g2f]], [[6g2o|6g2o]], [[6g3p|6g3p]]</td></tr> | ||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g3t OCA], [http://pdbe.org/6g3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g3t RCSB], [http://www.ebi.ac.uk/pdbsum/6g3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g3t ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Histone-lysine N-methyltransferase]] | |||
[[Category: Large Structures]] | |||
[[Category: Boettcher, J]] | [[Category: Boettcher, J]] | ||
[[Category: Muellauer, B J]] | |||
[[Category: Weiss-Puxbaum, A]] | [[Category: Weiss-Puxbaum, A]] | ||
[[Category: Zoephel, A]] | |||
[[Category: Inhibitor]] | |||
[[Category: Oncoprotein]] | |||
[[Category: Pwwp domain]] | |||
