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==Potent inhibitors of NUDT5 silence hormone signaling in breast cancer==
==Potent inhibitors of NUDT5 silence hormone signaling in breast cancer==
<StructureSection load='5nwh' size='340' side='right' caption='[[5nwh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5nwh' size='340' side='right'caption='[[5nwh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nwh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NWH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nwh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NWH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9CH:7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-piperazin-1-yl-purine-2,6-dione'>9CH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nwh OCA], [http://pdbe.org/5nwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nwh RCSB], [http://www.ebi.ac.uk/pdbsum/5nwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nwh ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9CH:7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-piperazin-1-yl-purine-2,6-dione'>9CH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nwh OCA], [https://pdbe.org/5nwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nwh RCSB], [https://www.ebi.ac.uk/pdbsum/5nwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nwh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NUDT5_HUMAN NUDT5_HUMAN]] Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.<ref>PMID:17052728</ref>
[https://www.uniprot.org/uniprot/NUDT5_HUMAN NUDT5_HUMAN] Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.<ref>PMID:17052728</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Carter, M]]
[[Category: Homo sapiens]]
[[Category: Stenmark, P]]
[[Category: Large Structures]]
[[Category: Hydrolase]]
[[Category: Carter M]]
[[Category: Inhibitor]]
[[Category: Stenmark P]]
[[Category: Nudix]]
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