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[[Image:2ghf.gif|left|200px]]


{{Structure
==Solution structure of the complete zinc-finger region of human zinc-fingers and homeoboxes 1 (ZHX1)==
|PDB= 2ghf |SIZE=350|CAPTION= <scene name='initialview01'>2ghf</scene>
<StructureSection load='2ghf' size='340' side='right'caption='[[2ghf]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[2ghf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GHF FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= ZHX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ghf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghf OCA], [https://pdbe.org/2ghf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ghf RCSB], [https://www.ebi.ac.uk/pdbsum/2ghf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ghf ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ghf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghf OCA], [http://www.ebi.ac.uk/pdbsum/2ghf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ghf RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/ZHX1_HUMAN ZHX1_HUMAN] Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.<ref>PMID:12237128</ref>
 
== Evolutionary Conservation ==
'''Solution structure of the complete zinc-finger region of human zinc-fingers and homeoboxes 1 (ZHX1)'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/2ghf_consurf.spt"</scriptWhenChecked>
2GHF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHF OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ghf ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: Wienk H]]
[[Category: Wienk, H.]]
[[Category: 4-stranded parallel/anti-parallel beta-sheet]]
[[Category: c2h2 zinc finger]]
[[Category: spine]]
[[Category: structural genomic]]
[[Category: structural proteomics in europe]]
 
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Retrieved from "https://proteopedia.org/2ghf"