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==Complex of MBP-C and Man-a13-Man==
==Complex of MBP-C and Man-a13-Man==
<StructureSection load='1kza' size='340' side='right' caption='[[1kza]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
<StructureSection load='1kza' size='340' side='right'caption='[[1kza]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KZA FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rdo|1rdo]], [[1kzb|1kzb]], [[1kzc|1kzc]], [[1kzd|1kzd]], [[1kze|1kze]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kza OCA], [https://pdbe.org/1kza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kza RCSB], [https://www.ebi.ac.uk/pdbsum/1kza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kza ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kza OCA], [http://pdbe.org/1kza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kza RCSB], [http://www.ebi.ac.uk/pdbsum/1kza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kza ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MBL2_RAT MBL2_RAT]] Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).  
[https://www.uniprot.org/uniprot/MBL2_RAT MBL2_RAT] Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Clark, D A]]
[[Category: Rattus norvegicus]]
[[Category: Drickamer, K]]
[[Category: Clark DA]]
[[Category: Feinberg, H]]
[[Category: Drickamer K]]
[[Category: Kolatkar, A R]]
[[Category: Feinberg H]]
[[Category: Ng, K K]]
[[Category: Kolatkar AR]]
[[Category: Park-Snyder, S]]
[[Category: Ng KK]]
[[Category: Weis, W I]]
[[Category: Park-Snyder S]]
[[Category: Immune system]]
[[Category: Weis WI]]
[[Category: Protein-carbohydrate complex]]
[[Category: Sugar binding protein]]
Retrieved from "https://proteopedia.org/1kza"