2izu: Difference between revisions

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==Structure of casein kinase gamma 3 in complex with inhibitor==
==Structure of casein kinase gamma 3 in complex with inhibitor==
<StructureSection load='2izu' size='340' side='right' caption='[[2izu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='2izu' size='340' side='right'caption='[[2izu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2izu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IZU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2izu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P01:2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL'>P01</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2chl|2chl]], [[2iur|2iur]], [[2izs|2izs]], [[2izt|2izt]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P01:2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL'>P01</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izu OCA], [https://pdbe.org/2izu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izu RCSB], [https://www.ebi.ac.uk/pdbsum/2izu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izu OCA], [http://pdbe.org/2izu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2izu RCSB], [http://www.ebi.ac.uk/pdbsum/2izu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2izu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Casein kinase|Casein kinase]]
*[[Casein kinase 3D structures|Casein kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith C]]
[[Category: Bunkoczi, G]]
[[Category: Bunkoczi G]]
[[Category: Das, S]]
[[Category: Das S]]
[[Category: Debreczeni, J E]]
[[Category: Debreczeni JE]]
[[Category: Delft, F von]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Fedorov O]]
[[Category: Fedorov, O]]
[[Category: Gileadi O]]
[[Category: Gileadi, O]]
[[Category: Knapp S]]
[[Category: Knapp, S]]
[[Category: Rellos P]]
[[Category: Rellos, P]]
[[Category: Salah E]]
[[Category: Salah, E]]
[[Category: Savitsky P]]
[[Category: Savitsky, P]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Von Delft F]]
[[Category: Atp- binding]]
[[Category: Kinase]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Serine/threonine kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Wnt signaling pathway]]

Latest revision as of 14:30, 13 December 2023

Structure of casein kinase gamma 3 in complex with inhibitor

2izu, resolution 1.85Å

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