5zmc: Difference between revisions

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'''Unreleased structure'''


The entry 5zmc is ON HOLD
==Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2==
<StructureSection load='5zmc' size='340' side='right'caption='[[5zmc]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zmc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZMC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zmc OCA], [https://pdbe.org/5zmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zmc RCSB], [https://www.ebi.ac.uk/pdbsum/5zmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zmc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETS1_HUMAN ETS1_HUMAN] Transcription factor.<ref>PMID:10698492</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Transcriptional factors ETS1/2 and p52 synergize downstream of non-canonical NF-kappaB signaling to drive reactivation of the -146C&gt;T mutant TERT promoter in multiple cancer types, but the mechanism underlying this cooperativity remains unknown. Here we report the crystal structure of a ternary p52/ETS1/-146C&gt;T TERT promoter complex. While p52 needs to associate with consensus kappaB sites on the DNA to function during non-canonical NF-kappaB signaling, we show that p52 can activate the -146C&gt;T TERT promoter without binding DNA. Instead, p52 interacts with ETS1 to form a heterotetramer, counteracting autoinhibition of ETS1. Analogous to observations with the GABPA/GABPB heterotetramer, the native flanking ETS motifs are required for sustained activation of the -146C&gt;T TERT promoter by the p52/ETS1 heterotetramer. These observations provide a unifying mechanism for transcriptional activation by GABP and ETS1, and suggest that genome-wide targets of non-canonical NF-kappaB signaling are not limited to those driven by consensus kappaB sequences.


Authors: Xu, X., Bharath, S.R., Song, H.
Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.,Xu X, Li Y, Bharath SR, Ozturk MB, Bowler MW, Loo BZL, Tergaonkar V, Song H Nat Commun. 2018 Aug 9;9(1):3183. doi: 10.1038/s41467-018-05644-0. PMID:30093619<ref>PMID:30093619</ref>


Description: Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Bharath, S.R]]
<div class="pdbe-citations 5zmc" style="background-color:#fffaf0;"></div>
[[Category: Song, H]]
== References ==
[[Category: Xu, X]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bharath SR]]
[[Category: Song H]]
[[Category: Xu X]]
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