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==The structure of DrFam20C1 and hFam20A complex==
==The structure of DrFam20C1 and hFam20A complex==
<StructureSection load='5yh2' size='340' side='right' caption='[[5yh2]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
<StructureSection load='5yh2' size='340' side='right'caption='[[5yh2]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5yh2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YH2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5yh2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YH2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yh2 OCA], [http://pdbe.org/5yh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yh2 RCSB], [http://www.ebi.ac.uk/pdbsum/5yh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yh2 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yh2 OCA], [https://pdbe.org/5yh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yh2 RCSB], [https://www.ebi.ac.uk/pdbsum/5yh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yh2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Amelogenesis imperfecta - nephrocalcinosis;Amelogenesis imperfecta and gingival hyperplasia syndrome. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN] Amelogenesis imperfecta - nephrocalcinosis;Amelogenesis imperfecta and gingival hyperplasia syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<ref>PMID:25789606</ref>
[https://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN] Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<ref>PMID:25789606</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Xiao, J]]
[[Category: Danio rerio]]
[[Category: Zhang, H]]
[[Category: Homo sapiens]]
[[Category: Complex]]
[[Category: Large Structures]]
[[Category: Kinase]]
[[Category: Xiao J]]
[[Category: Transferase]]
[[Category: Zhang H]]
Retrieved from "https://proteopedia.org/5yh2"