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==Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate==
==Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate==
<StructureSection load='6ax8' size='340' side='right' caption='[[6ax8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6ax8' size='340' side='right'caption='[[6ax8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ax8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AX8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ax8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AX8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ME8:[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]+(2S)-2-AZANYL-4-METHYLSULFANYL-BUTANOATE'>ME8</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ME8:[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]+(2S)-2-AZANYL-4-METHYLSULFANYL-BUTANOATE'>ME8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ax8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ax8 OCA], [http://pdbe.org/6ax8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ax8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ax8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ax8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ax8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ax8 OCA], [https://pdbe.org/6ax8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ax8 RCSB], [https://www.ebi.ac.uk/pdbsum/6ax8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ax8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SYM_MYCTU SYM_MYCTU]] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.  
[https://www.uniprot.org/uniprot/SYM_MYCTU SYM_MYCTU] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Methionine--tRNA ligase]]
[[Category: Large Structures]]
[[Category: Barros-Alvarez, X]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Hol, W G.J]]
[[Category: Barros-Alvarez X]]
[[Category: Ligase]]
[[Category: Hol WGJ]]
[[Category: Ligase-aminoacyl adenylate complex]]
[[Category: Synthetase]]

Latest revision as of 14:19, 13 March 2024

Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate

6ax8, resolution 2.60Å

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