6bxk: Difference between revisions
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==Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and MTA== | ==Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and MTA== | ||
<StructureSection load='6bxk' size='340' side='right' caption='[[6bxk]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='6bxk' size='340' side='right'caption='[[6bxk]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6bxk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXK OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6bxk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BXK FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.347Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxk OCA], [https://pdbe.org/6bxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bxk RCSB], [https://www.ebi.ac.uk/pdbsum/6bxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DPH2_PYRHO DPH2_PYRHO] Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).<ref>PMID:20559380</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Carantoa | [[Category: Large Structures]] | ||
[[Category: Dong | [[Category: Pyrococcus horikoshii OT3]] | ||
[[Category: Dzikovski | [[Category: Carantoa JD]] | ||
[[Category: Ealick | [[Category: Dong M]] | ||
[[Category: Fenwick | [[Category: Dzikovski B]] | ||
[[Category: Freed | [[Category: Ealick SE]] | ||
[[Category: Hoffman | [[Category: Fenwick MK]] | ||
[[Category: Kathiresan | [[Category: Freed JH]] | ||
[[Category: Lancaster | [[Category: Hoffman BM]] | ||
[[Category: Lin | [[Category: Kathiresan V]] | ||
[[Category: Torelli | [[Category: Lancaster KM]] | ||
[[Category: Zhang | [[Category: Lin H]] | ||
[[Category: Torelli AT]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 13:03, 13 August 2026
Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and MTA
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