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==Crystal Structure of Rhodesain in complex with a Macrolactam Inhibitor==
==Crystal Structure of Rhodesain in complex with a Macrolactam Inhibitor==
<StructureSection load='6ex8' size='340' side='right' caption='[[6ex8]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='6ex8' size='340' side='right'caption='[[6ex8]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ex8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EX8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ex8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EX8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2K:(3~{S})-~{N}-[1-(aminomethyl)cyclopropyl]-19-chloranyl-5-oxidanylidene-9-(trifluoromethyl)-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(20),6(11),7,9,18,21-hexaene-3-carboxamide'>C2K</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2K:(3~{S})-19-chloranyl-~{N}-(1-cyanocyclopropyl)-5-oxidanylidene-9-(trifluoromethyl)-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6(11),7,9,18(22),19-hexaene-3-carboxamide'>C2K</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ex8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ex8 OCA], [http://pdbe.org/6ex8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ex8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ex8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ex8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ex8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ex8 OCA], [https://pdbe.org/6ex8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ex8 RCSB], [https://www.ebi.ac.uk/pdbsum/6ex8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ex8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q95PM0_TRYBR Q95PM0_TRYBR]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dietzel, U]]
[[Category: Large Structures]]
[[Category: Kisker, C]]
[[Category: Trypanosoma brucei rhodesiense]]
[[Category: Cathepsin l-like protease]]
[[Category: Dietzel U]]
[[Category: Cysteine protease]]
[[Category: Kisker C]]
[[Category: Endopeptidase]]
[[Category: Hydrolase]]
[[Category: Papain-like protease]]
Retrieved from "https://proteopedia.org/6ex8"